Publications
2024
- Bettin I., Brattini M., Kachoie EA., Capaldi S., Thalappil MA., Bernardi P., Ferrarini I., Fuhrmann G., Mariotto S., Butturini E.:
Extracellular Vesicles based STAT3 delivery as innovative therapeutic approach to restore STAT3 signaling deficiency
In: New Biotechnology 82 (2024), S. 43-53
ISSN: 1871-6784
DOI: 10.1016/j.nbt.2024.05.001 - Dorner H., Stolzer I., Mattner J., Kaminski S., Leistl S., Edrich LM., Schwendner R., Hobauer J., Sebald A., Leikam S., Gonzalez Acera M., Düll M., Lang R., Seidel G., Seitz T., Hellerbrand C., Fuhrmann G., Distler U., Tenzer S., Eichhorn P., Vieth M., Schramm C., Arnold P., Becker C., Weidinger C., Siegmund B., Atreya R., Leppkes M., Naschberger E., Sampaziotis F., Dietrich P., Rauh M., Wirtz S., Kremer A., Neurath M., Günther C.:
Gut Pathobiont–Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in Primary Sclerosing Cholangitis–Associated Inflammatory Bowel Disease
In: Gastroenterology (2024)
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2024.06.032 - Fuhrmann G., Mehanny M.:
Spray Drying of Bacterial Membrane Vesicles for Vaccine Delivery
In: Methods in Molecular Biology 2843 (2024), S. 163-175
ISSN: 1064-3745
DOI: 10.1007/978-1-0716-4055-5_11 - Kuhn T., Aljohmani A., Frank N., Zielke L., Mehanny M., Laschke MW., Koch M., Hoppstädter J., Kiemer AK., Yildiz D., Fuhrmann G.:
A cell-free, biomimetic hydrogel based on probiotic membrane vesicles ameliorates wound healing
In: Journal of Controlled Release 365 (2024), S. 969-980
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2023.12.011 - Mashayekhi V., Schomisch A., Rasheed S., Aparicio-Puerta E., Risch T., Yildiz D., Koch M., Both S., Ludwig N., Legroux TM., Keller A., Müller R., Fuhrmann G., Hoppstädter J., Kiemer AK.:
The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages
In: Cell Communication and Signaling 22 (2024), Art.Nr.: 344
ISSN: 1478-811X
DOI: 10.1186/s12964-024-01701-y - Poupardin R., Wolf M., Maeding N., Paniushkina L., Geissler S., Bergese P., Witwer KW., Schallmoser K., Fuhrmann G., Strunk D.:
Advances in Extracellular Vesicle Research Over the Past Decade: Source and Isolation Method are Connected with Cargo and Function
In: Advanced Healthcare Materials (2024)
ISSN: 2192-2640
DOI: 10.1002/adhm.202303941
2023
- Fuhrmann G.:
Drug delivery as a sustainable avenue to future therapies
In: Journal of Controlled Release 354 (2023), S. 746-754
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2023.01.045 - Heinrich E., Hartwig O., Walt C., Kardani A., Koch M., Jahromi LP., Hoppstaedter J., Kiemer AK., Loretz B., Lehr CM., Fuhrmann G.:
Cell-Derived Vesicles for Antibiotic Delivery-Understanding the Challenges of a Biogenic Carrier System
In: Small (2023)
ISSN: 1613-6829
DOI: 10.1002/smll.202207479 - Pourtalebi Jahromi L., Rothammer M., Fuhrmann G.:
Polysaccharide hydrogel platforms as suitable carriers of liposomes and extracellular vesicles for dermal applications
In: Advanced Drug Delivery Reviews 200 (2023), Art.Nr.: 115028
ISSN: 0169-409X
DOI: 10.1016/j.addr.2023.115028 - Zivko C., Witt F., Koeberle A., Fuhrmann G., Luciani P.:
Formulating elafibranor and obeticholic acid with phospholipids decreases drug-induced association of SPARC to extracellular vesicles from LX-2 human hepatic stellate cells
In: European Journal of Pharmaceutics and Biopharmaceutics 182 (2023), S. 32-40
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2022.11.025
2022
- Drost M., Diamanti E., Fuhrmann K., Goes A., Shams A., Haupenthal J., Koch M., Hirsch AK., Fuhrmann G.:
Bacteriomimetic liposomes improve antibiotic activity of a novel energy-coupling factor transporter inhibitor
In: Pharmaceutics 14 (2022), Art.Nr.: 4
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics14010004 - Fuhrmann G., Lehr CM., Schiffelers R.:
Themed issue: Extracellular vesicles in drug delivery and bioengineering
In: Advanced Drug Delivery Reviews 181 (2022), Art.Nr.: 114073
ISSN: 0169-409X
DOI: 10.1016/j.addr.2021.114073 - Lapuhs P., Heinrich E., Garcia R., Goes A., Frank N., Bollenbach L., Stibane V., Kuhn T., Koch M., Kiemer AK., Müller R., Fuhrmann K., Fuhrmann G.:
The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation
In: Nanoscale (2022)
ISSN: 2040-3364
DOI: 10.1039/d2nr02743g - Mehanny M., Boese A., Bornamehr B., Hoppstädter J., Presser V., Kiemer AK., Lehr CM., Fuhrmann G.:
Spray-dried pneumococcal membrane vesicles are promising candidates for pulmonary immunization
In: International Journal of Pharmaceutics 621 (2022), Art.Nr.: 121794
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2022.121794 - Nguyen J., Fuhrmann G.:
Extracellular Vesicles — A Versatile Biomaterial
In: Advanced Healthcare Materials 11 (2022), Art.Nr.: 2200192
ISSN: 2192-2640
DOI: 10.1002/adhm.202200192 - Zivko C., Fuhrmann K., Fuhrmann G., Luciani P.:
Tracking matricellular protein SPARC in extracellular vesicles as a non-destructive method to evaluate lipid-based antifibrotic treatments
In: Communications Biology 5 (2022), Art.Nr.: 1155
ISSN: 2399-3642
DOI: 10.1038/s42003-022-04123-z
2021
- Fuhrmann G., Loretz B., Schneider-Daum N., Lehr CM.:
Biobarriers 2018
In: European Journal of Pharmaceutics and Biopharmaceutics 158 (2021), S. 52-
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2020.10.014 - Herrmann IK., Wood MJA., Fuhrmann G.:
Extracellular vesicles as a next-generation drug delivery platform
In: Nature nanotechnology (2021)
ISSN: 1748-3395
DOI: 10.1038/s41565-021-00931-2 - Jahromi LP., Fuhrmann G.:
Bacterial extracellular vesicles: Understanding biology promotes applications as nanopharmaceuticals
In: Advanced Drug Delivery Reviews 173 (2021), S. 125-140
ISSN: 0169-409X
DOI: 10.1016/j.addr.2021.03.012 - Mehanny M., Kroniger T., Koch M., Hoppstädter J., Becher D., Kiemer AK., Lehr CM., Fuhrmann G.:
Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase
In: Advanced Healthcare Materials (2021)
ISSN: 2192-2640
DOI: 10.1002/adhm.202101151 - Mehanny M., Lehr CM., Fuhrmann G.:
Extracellular vesicles as antigen carriers for novel vaccination avenues
In: Advanced Drug Delivery Reviews 173 (2021), S. 164-180
ISSN: 0169-409X
DOI: 10.1016/j.addr.2021.03.016 - Mueller L., Kuhn T., Koch M., Fuhrmann G.:
Stimulation of Probiotic Bacteria Induces Release of Membrane Vesicles with Augmented Anti-inflammatory Activity
In: ACS Applied Bio Materials (2021)
ISSN: 2576-6422
DOI: 10.1021/acsabm.0c01136 - Richter M., Vader P., Fuhrmann G.:
Approaches to surface engineering of extracellular vesicles
In: Advanced Drug Delivery Reviews 173 (2021), S. 416-426
ISSN: 0169-409X
DOI: 10.1016/j.addr.2021.03.020 - Trousil J., Aryal S., Fuhrmann G.:
Biogenic and biomimetic nanocarrier-based interventions: Focus on intracellular infections
In: Nanomedicine 16 (2021), S. 685-688
ISSN: 1743-5889
DOI: 10.2217/nnm-2021-0052 - Zivko C., Fuhrmann G., Luciani P.:
Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices
In: Biochimica Et Biophysica Acta-General Subjects 1865 (2021), Art.Nr.: 129559
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2020.129559
2020
- Fuhrmann G.:
Diffusion and transport of extracellular vesicles
In: Nature nanotechnology 15 (2020), S. 168-169
ISSN: 1748-3395
DOI: 10.1038/s41565-020-0651-3 - Goes A., Lapuhs P., Kuhn T., Schulz E., Richter R., Panter F., Dahlem C., Koch M., Garcia R., Kiemer AK., Mueller R., Fuhrmann G.:
Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections
In: Cells 9 (2020)
ISSN: 2073-4409
DOI: 10.3390/cells9010194 - Kuhn T., Koch M., Fuhrmann G.:
Probiomimetics—Novel Lactobacillus-Mimicking Microparticles Show Anti-Inflammatory and Barrier-Protecting Effects in Gastrointestinal Models
In: Small 16 (2020), Art.Nr.: 2003158
ISSN: 1613-6829
DOI: 10.1002/smll.202003158 - Mehanny M., Koch M., Lehr CM., Fuhrmann G.:
Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release
In: Frontiers in Immunology 11 (2020), Art.Nr.: 80
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.00080 - Montefusco-Pereira C., Formicola B., Goes A., Re F., Marrano CA., Mantegazza F., Carvalho-Wodarz C., Fuhrmann G., Caneva E., Nicotra F., Lehr CM., Russo L.:
Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility
In: European Journal of Pharmaceutics and Biopharmaceutics 149 (2020), S. 12-20
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2020.01.013 - Schulz E., Karagianni A., Koch M., Fuhrmann G.:
Hot EVs – How temperature affects extracellular vesicles
In: European Journal of Pharmaceutics and Biopharmaceutics 146 (2020), S. 55-63
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2019.11.010 - Whitworth DE., Jurkevitch E., Perez J., Fuhrmann G., Koval SF.:
Editorial: Mechanisms of Prokaryotic Predation
In: Frontiers in Microbiology 11 (2020), Art.Nr.: 2071
ISSN: 1664-302X
DOI: 10.3389/fmicb.2020.02071
2019
- Hoppstaedter J., Dembek A., Linnenberger R., Dahlem C., Barghash A., Fecher-Trost C., Fuhrmann G., Koch M., Kraegeloh A., Huwer H., Kiemer AK.:
Toll-Like Receptor 2 Release by Macrophages: An Anti-inflammatory Program Induced by Glucocorticoids and Lipopolysaccharide
In: Frontiers in Immunology 10 (2019), S. 1634-
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.01634 - Lapuhs P., Fuhrmann G.:
Engineering strategies for oral therapeutic enzymes to enhance their stability and activity
In: Advances in Experimental Medicine and Biology, Springer New York LLC, 2019, S. 151-172 (Advances in Experimental Medicine and Biology, Bd.1148)
DOI: 10.1007/978-981-13-7709-9_8 - Richter M., Fuhrmann K., Fuhrmann G.:
Evaluation of the storage stability of extracellular vesicles
In: Journal of Visualized Experiments 2019 (2019), Art.Nr.: e59584
ISSN: 1940-087X
DOI: 10.3791/59584 - Schulz E., Goes A., Garcia R., Panter F., Koch M., Mueller R., Fuhrmann K., Fuhrmann G.:
Corrigendum to biocompatible bacteria-derived vesicles show inherent antimicrobial activity (Journal of Controlled Release (2018) 290 (46–55), (S0168365918305698) (10.1016/j.jconrel.2018.09.030))
In: Journal of Controlled Release 293 (2019), S. 155-157
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2018.11.027 - Woith E., Fuhrmann G., Melzig MF.:
Extracellular vesicles—connecting kingdoms
In: International Journal of Molecular Sciences 20 (2019), Art.Nr.: 5695
ISSN: 1422-0067
DOI: 10.3390/ijms20225695
2018
- Frank J., Richter M., De Rossi C., Lehr CM., Fuhrmann K., Fuhrmann G.:
Extracellular vesicles protect glucuronidase model enzymes during freeze-drying
In: Scientific Reports 8 (2018), Art.Nr.: 12377
ISSN: 2045-2322
DOI: 10.1038/s41598-018-30786-y - Fuhrmann G.:
Luminal coating of the intestine
In: Nature Materials 17 (2018), S. 754-755
ISSN: 1476-4660
DOI: 10.1038/s41563-018-0143-0 - Fuhrmann G., Chandrawati R., Parmar PA., Keane TJ., Maynard SA., Bertazzo S., Stevens MM.:
Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy
In: Advanced Materials 30 (2018), Art.Nr.: 1706616
ISSN: 0935-9648
DOI: 10.1002/adma.201706616 - Goes A., Fuhrmann G.:
Biogenic and Biomimetic Carriers as Versatile Transporters to Treat Infections
In: ACS Infectious Diseases 4 (2018), S. 881-892
ISSN: 2373-8227
DOI: 10.1021/acsinfecdis.8b00030 - Schulz E., Goes A., Garcia R., Panter F., Koch M., Mueller R., Fuhrmann K., Fuhrmann G.:
Biocompatible bacteria-derived vesicles show inherent antimicrobial activity
In: Journal of Controlled Release 290 (2018), S. 46-55
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2018.09.030
2017
2015
- Fuhrmann G., Herrmann IK., Stevens MM.:
Cell-derived vesicles for drug therapy and diagnostics: Opportunities and challenges
In: Nano Today 10 (2015), S. 397-409
ISSN: 1748-0132
DOI: 10.1016/j.nantod.2015.04.004 - Fuhrmann G., Serio A., Mazo M., Nair R., Stevens MM.:
Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins
In: Journal of Controlled Release 205 (2015), S. 35-44
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2014.11.029 - Santos L., Fuhrmann G., Juenet M., Amdursky N., Horejs CM., Campagnolo P., Stevens MM.:
Extracellular Stiffness Modulates the Expression of Functional Proteins and Growth Factors in Endothelial Cells
In: Advanced Healthcare Materials 4 (2015), S. 2056-2063
ISSN: 2192-2640
DOI: 10.1002/adhm.201500338
2014
2013
- Fuhrmann G., Gauthier MA., Leroux JC.:
Polymer-enzyme conjugates for oral drug delivery applications
In: Chimia 67 (2013), S. 685-
ISSN: 0009-4293
DOI: 10.2533/chimia.2013.685 - Fuhrmann G., Grotzky A., Lukic R., Matoori S., Luciani P., Yu H., Zhang B., Walde P., Schlueter AD., Gauthier MA., Leroux JC.:
Sustained gastrointestinal activity of dendronized polymer-enzyme conjugates
In: Nature Chemistry 5 (2013), S. 582-589
ISSN: 1755-4330
DOI: 10.1038/nchem.1675 - Matoori S., Fuhrmann G., Leroux JC.:
Celiac disease: A challenging disease for pharmaceutical scientists
In: Pharmaceutical Research 30 (2013), S. 619-626
ISSN: 0724-8741
DOI: 10.1007/s11095-012-0951-x
2012
- Pinier M., Fuhrmann G., Galipeau HJ., Rivard N., Murray JA., David CS., Drasarova H., Tuckova L., Leroux JC., Verdu EF.:
The copolymer P(HEMA-co-SS) binds gluten and reduces immune response in gluten-sensitized mice and human tissues
In: Gastroenterology 142 (2012), S. 316-325.e12
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2011.10.038
2011
2010
- Bastiat G., Plourde F., Motulsky A., Furtos A., Dumont Y., Quirion R., Fuhrmann G., Leroux JC.:
Tyrosine-based rivastigmine-loaded organogels in the treatment of Alzheimer's disease
In: Biomaterials 31 (2010), S. 6031-6038
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2010.04.009 - Fuhrmann G., Leroux JC.:
In vitro evaluation of the stability of proline-specific endopeptidases under simulated gastrointestinal conditions.
In: Journal of Controlled Release 148 (2010), S. e37-39
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2010.07.046 - Pinier M., Fuhrmann G., Verdu E., Leroux JC.:
Prevention measures and exploratory pharmacological treatments of celiac disease
In: American Journal of Gastroenterology 105 (2010), S. 2551-2561
ISSN: 0002-9270
DOI: 10.1038/ajg.2010.372