Jennifer Munkert

2023

• Leykauf T., Klein J., Ernst M., Dorfner M., Ignatova A., Kreis W., Lanig H., Munkert J.:
  Overexpression and RNAi-mediated Knockdown of Two 3β-hydroxy-Δ5-steroid dehydrogenase Genes in Digitalis lanata Shoot Cultures Reveal Their Role in Cardenolide Biosynthesis
  In: Planta Medica 89 (2023), S. 833-847
  ISSN: 0032-0943
  DOI: 10.1055/a-2074-9186
• Marafeli ÉAM., Chibli LA., Rocha JPM., Assis RMAd., Pinto JEBP., Pádua RMd., Kreis W., Munkert J., Braga FC., Bertolucci SKV.:
  Photoconverting nets affect plant growth and levels of antiviral glucoevatromonoside and total cardenolides in Digitalis mariana ssp. heywoodii (P. Silva and M. Silva) Hinz
  In: Industrial Crops and Products 204 (2023), Art.Nr.: 117348
  ISSN: 0926-6690
  DOI: 10.1016/j.indcrop.2023.117348

2022

• De Padua RM., Kratz JM., Munkert J., Bertol JW., Rigotto C., Schuster D., Maltarollo VG., Kreis W., Oliveira Simoes CM., Braga FC.:
  Effects of Lipophilicity and Structural Features on the Antiherpes Activity of Digitalis Cardenolides and Derivatives
  In: Chemistry & Biodiversity (2022)
  ISSN: 1612-1872
  DOI: 10.1002/cbdv.202200411
• Klein J., Ernst M., Christmann A., Tropper M., Leykauf T., Kreis W., Munkert J.:
  Knockout of arabidopsis thaliana vep1, encoding a prise (Progesterone 5β-reductase/iridoid synthase-like enzyme), leads to metabolic changes in response to exogenous methyl vinyl ketone (mvk)
  In: Metabolites 12 (2022), Art.Nr.: 11
  ISSN: 2218-1989
  DOI: 10.3390/metabo12010011

2021

• Dorfner M., Klein J., Lanig H., Kreis W., Munkert J.:
  Identifying structural features for changing substrate preferences in two Plantago PRISEs (pro-gesterone 5 beta-reductase and / or iridoid synthase)
  In: PLANTA MEDICA, STUTTGART: 2021
  DOI: 10.1055/s-0041-1736952
• Ignatova A., Klein J., Leykauf T., Kreis W., Munkert J.:
  Restoring cardenolide accumulation in RNAi-mediated DlP5 beta R1 and DlP5 beta R2 knockdown shoot culture lines of Digitalis lanata and studying the effects of precursor feeding on cardenolide free dark-cultured D. lanata shoots
  In: PLANTA MEDICA, STUTTGART: 2021
  DOI: 10.1055/s-0041-1736902
• Klein J., Horn E., Ernst M., Leykauf T., Leupold T., Dorfner M., Wolf LS., Ignatova A., Kreis W., Munkert J.:
  RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content
  In: Plant Cell Reports (2021)
  ISSN: 0721-7714
  DOI: 10.1007/s00299-021-02707-3
• Leykauf T., Klein J., Lodel M., Kreis W., Munkert J.:
  Overexpression of 3 beta-hydroxysteroid dehydrogenases in Digitalis lanata shoot cultures
  In: PLANTA MEDICA, STUTTGART: 2021
  DOI: 10.1055/s-0041-1736957
• Tropper M., Höhn S., Wolf LS., Fritsch J., Kastner-Detter N., Rieck C., Munkert J., Meitinger N., Lanig H., Kreis W.:
  21-Hydroxypregnane 21-O-malonylation, a crucial step in cardenolide biosynthesis, can be achieved by substrate-promiscuous BAHD-type phenolic glucoside malonyltransferases from Arabidopsis thaliana and homolog proteins from Digitalis lanata
  In: Phytochemistry 187 (2021), Art.Nr.: 112710
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2021.112710
• Zanchett Schneider NF., Menegaz D., Andreotti Dagostin AL., Persich L., Rocha SC., Pacheco Ramos AC., Cortes VF., Leite Fontes CF., De Padua RM., Munkert J., Kreis W., Braga FC., Barbosa LA., Mena Barreto Silva FR., Oliveira Simoes CM.:
  Cytotoxicity of glucoevatromonoside alone and in combination with chemotherapy drugs and their effects on Na+,K+-ATPase and ion channels on lung cancer cells
  In: Molecular and Cellular Biochemistry (2021)
  ISSN: 0300-8177
  DOI: 10.1007/s11010-020-04040-x

2020

• Boff L., Persich L., Brambila P., Ottoni FM., Munkert J., Ramos GS., Soares Viana AR., Kreis W., Braga FC., Alves RJ., Maia de Pádua R., Schneider NFZ., Simões CMO.:
  Investigation of the cytotoxic activity of two novel digitoxigenin analogues on H460 lung cancer cells
  In: Anti-Cancer Drugs 31 (2020), S. 452-462
  ISSN: 0959-4973
  DOI: 10.1097/CAD.0000000000000872
• Boff L., Schneider NFZ., Munkert J., Ottoni FM., Ramos GS., Kreis W., Braga FC., Alves RJ., Maia de Pádua R., Simões CMO.:
  Elucidation of the mechanism of anti-herpes action of two novel semisynthetic cardenolide derivatives.
  In: Archives of Virology (2020), S. 1385-1396
  ISSN: 0304-8608
  DOI: 10.1007/s00705-020-04562-1
• Boff L., Schreiber A., Matos AdR., Del Sarto JL., Brunotte L., Munkert J., Ottoni FM., Ramos GS., Kreis W., Braga FC., Alves RJ., Maia de Pádua R., Simões CMO., Ludwig S.:
  Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation
  In: Molecules (2020)
  ISSN: 1420-3049
  DOI: 10.3390/molecules25204853
• Freitas CS., Oliveira-da-Silva JA., Lage DP., Costa RR., Mendonça DV., Martins VT., Reis TA., Antinarelli LM., Machado AS., Tavares GS., Ramos FF., Coelho VT., Brito RC., Ludolf F., Chávez-Fumagalli MA., Roatt BM., Ramos GS., Munkert J., Ottoni FM., Campana PR., Humbert MV., Coimbra ES., Braga FC., Pádua RM., Coelho EA.:
  Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis
  In: Parasitology Research (2020)
  ISSN: 0932-0113
  DOI: 10.1007/s00436-020-06971-2
• Horn E., Kemmler Y., Kreis W., Munkert J.:
  Cardenolide and glucosinolate accumulation in shoot cultures of Erysimum crepidifolium Rchb.
  In: In Vitro Cellular & Developmental Biology-Plant (2020)
  ISSN: 1054-5476
  DOI: 10.1007/s11627-020-10135-3

2019

• Boff L., Munkert J., Ottoni FM., Schneider NFZ., Ramos GS., Kreis W., Andrade SF., De Souza Filho JD., Braga FC., Alves RJ., De Padua RM., Simões CMO.:
  Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives
  In: European Journal of Medicinal Chemistry 167 (2019), S. 546-561
  ISSN: 0223-5234
  DOI: 10.1016/j.ejmech.2019.01.076
• Boff L., Munkert J., Ottoni FM., Zanchett Schneider NF., Ramos GS., Kreis W., De Andrade SF., Dias De Souza Filho J., Castro Braga F., Alves RJ., Maia De Padua R., Simões CMO.:
  Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives
  67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck, 1. September 2019 - 5. September 2019)
  In: PLANTA MEDICA, STUTTGART: 2019
  DOI: 10.1055/s-0039-3399709
• Kreis W., Munkert J.:
  Exploiting enzyme promiscuity to shape plant specialized metabolism
  In: Journal of Experimental Botany 70 (2019), S. 1435-1445
  ISSN: 0022-0957
  DOI: 10.1093/jxb/erz025
• Leykauf T., Klein J., Ernst M., Kreis W., Munkert J.:
  RNAi mediated knock down of 3 beta-hydroxysteroid dehydrogenases in Digitalis lanata shoot cultures
  67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck, 1. September 2019 - 5. September 2019)
  In: PLANTA MEDICA, STUTTGART: 2019
  DOI: 10.1055/s-0039-3399800
• Munkert J., Gomes ER., Marostica LL., Cota BB., Lopes CL., Andrade SF., Filho JDS., Alves RJ., Oliveira MC., Braga FC., Simões CM., Pádua RM., De Barros AL.:
  New 99mTc-Labeled Digitoxigenin Derivative for Cancer Cell Identification
  In: ACS Omega (2019)
  ISSN: 2470-1343
  DOI: 10.1021/acsomega.9b03167
• Rieck C., Geiger D., Munkert J., Messerschmidt K., Petersen J., Strasser J., Meitinger N., Kreis W.:
  Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae
  In: MicrobiologyOpen (2019), Art.Nr.: e925
  ISSN: 2045-8827
  DOI: 10.1002/mbo3.925
• Tropper M., Höhn S., Munkert J., Kreis W.:
  BAHD-like malonyltransferase genes from Digitalis lanata and Arabidopsis thaliana and their putative role in cardenolide biosynthesis
  67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck, 1. September 2019 - 5. September 2019)
  In: PLANTA MEDICA, STUTTGART: 2019
  DOI: 10.1055/s-0039-3399788

2018

• Gomes ER., Novais MVM., Silva IT., Barros ALB., Leite EA., Munkert J., Frade ACM., Cassali GD., Braga FC., De Padua RM., Oliveira MC.:
  Long-circulating and fusogenic liposomes loaded with a glucoevatromomoside derivative induce potent antitumor response
  In: Biomedicine & Pharmacotherapy (2018), S. 1152 - 1161
  ISSN: 0753-3322
  DOI: 10.1016/j.biopha.2018.09.109
• Schmidt K., Petersen J., Munkert J., Egerer-Sieber C., Hornig M., Muller Y., Kreis W.:
  PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism.
  In: Phytochemistry 156 (2018), S. 9-19
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2018.08.012
• Schneider NFZ., Cerella C., Lee JY., Mazumder A., Kim KR., de Carvalho A., Munkert J., De Padua RM., Kreis W., Kim KW., Christov C., Dicato M., Kim HJ., Han BW., Braga FC., Simões CMO., Diederich M.:
  Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-specific Cell Death
  In: Frontiers in Pharmacology 9 (2018), Art.Nr.: 70
  ISSN: 1663-9812
  DOI: 10.3389/fphar.2018.00070
• Silva IT., Munkert J., Nolte E., Schneider NFZ., Rocha SC., Ramos ACP., Kreis W., Braga FC., De Padua RM., Taranto AG., Cortes VF., Barbosa LA., Wach S., Taubert H., Simões CMO.:
  Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+ -ATPase inhibition.
  In: Biomedicine & Pharmacotherapy 107 (2018), S. 464-474
  ISSN: 0753-3322
  DOI: 10.1016/j.biopha.2018.08.028

2017

• Kreis W., Munkert J., De Padua RM.:
  Biossíntese de metabólitos primários e secundários
  In: Letícia Bispo de Lima (Hrsg.): Farmacognosia do Produto Natural ao Medicamento, Porto Alegre, Brazil: Artmed Editora Ltda., 2017, S. 147 - 166
  ISBN: 978-85-8271-359-4
• Munkert J., Kreis W.:
  Herzglykoside und ihr Potenzial für die Tumortherapie
  In: Deutsche Zeitschrift für Onkologie 49 (2017), S. 129-135
  ISSN: 0931-0037
  DOI: 10.1055/s-0043-115681
• Munkert J., Santiago Franco M., Nolte E., Silva IT., Oliveira Castilho R., Ottoni FM., Schneider NFZ., Oliveira MC., Taubert H., Bauer W., Andrade SF., Alves RJ., Simões CMO., Braga FC., Kreis W., De Padua RM.:
  Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture.
  In: Planta medica (2017)
  ISSN: 1439-0221
  DOI: 10.1055/s-0043-109557
• Nolte E., Wach S., Silva IT., Lukat S., Ekici AB., Munkert J., Müller-Uri F., Kreis W., Simões CMO., Vera González J., Wullich B., Taubert H., Lai X.:
  A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines
  In: Oncotarget 8 (2017), S. 11676-11691
  ISSN: 1949-2553
  DOI: 10.18632/oncotarget.14644
• Schneider NFZ., Persich L., Rocha SC., Ramos ACP., Cortes VF., Silva IT., Munkert J., De Padua RM., Kreis W., Taranto AG., Barbosa LA., Braga FC., Simões CMO.:
  Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase
  In: Biomedicine & Pharmacotherapy 97 (2017), S. 684-696
  ISSN: 0753-3322
  DOI: 10.1016/j.biopha.2017.10.128

2016

• Meitinger N., Munkert J., Maia de Pádua R., De Souza Filho JD., Maid H., Bauer W., Braga FC., Kreis W.:
  The catalytic mechanism of the 3-ketosteroid isomerase of Digitalis lanata involves an intramolecular proton transfer and the activity is not associated with the 3 beta-hydroxysteroid dehydrogenase activity
  In: Tetrahedron Letters 57 (2016), S. 1567-1571
  ISSN: 0040-4039
  DOI: 10.1016/j.tetlet.2016.02.099

2015

• Ernst M., Munkert J., Campa M., Malnoy M., Martens S., Müller-Uri F.:
  Steroid 5β-reductase from leaves of Vitis vinifera: molecular cloning, expression and modelling
  In: Journal of Agricultural and Food Chemistry 63 (2015), S. 10112–10120
  ISSN: 0021-8561
  DOI: 10.1021/acs.jafc.5b04261
• Munkert J., Costa C., Budeanu O., Petersen J., Bertolucci S., Fischer G., Müller-Uri F., Kreis W.:
  Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers
  In: Plant Biology 17 (2015), S. 1113-1122
  ISSN: 1435-8603
  DOI: 10.1111/plb.12361
• Munkert J., Pollier J., Miettinen K., Van Moerkercke A., Payne R., Müller-Uri F., Burlat V., O'Connor SE., Memelink J., Kreis W., Goossens A.:
  Iridoid Synthase Activity is Common among the Plant Progesterone 5β-Reductase Family
  In: Molecular Plant 8 (2015), S. 136-152
  ISSN: 1674-2052
  DOI: 10.1016/j.molp.2014.11.005
• Petersen J., Lanig H., Munkert J., Bauer P., Müller-Uri F., Kreis W.:
  Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations
  In: Journal of Biomolecular Structure & Dynamics (2015), S. 1-14
  ISSN: 0739-1102
  DOI: 10.1080/07391102.2015.1088797

2014

• Munkert J., Ernst M., Müller-Uri F., Kreis W.:
  Identification and stress-induced expression of three 3β-hydroxysteroid dehydrogenases from Erysimum crepidifolium Rchb. and their putative role in cardenolide biosynthesis
  In: Phytochemistry 100 (2014), S. 26-33
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2014.01.006

2011

• Bauer P., Müller-Uri F., Kreis W., Burda E., Munkert J.:
  Progesterone 5β-reductase of Erysimum crepidifolium: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant protein
  In: Phytochemistry 72 (2011), S. 1710-1717
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2011.06.007

2010

• Bauer P., Munkert J., Brydziun M., Burda E., Müller-Uri F., Gröger H., Muller Y., Kreis W.:
  Highly conserved progesterone 5β-reductase (P5βR) genes, from 5β-cardenolide-free and 5β-cardenolide-producing angiosperms.
  In: Phytochemistry 71 (2010), S. 1495-1505
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2010.06.004